Erythrocyte-erythrocyte aggregation dynamics under shear flow

Erythrocyte deformation under shear flow.

Mechanism of erythrocyte aggregation and sedimentation.

Unstirred suspensions of erythrocytes form stable spherical aggregates of uniform size. The radius of the spheres depends upon the suspending medium and the hematocrit. Erythrocyte suspensions will undergo sedimentation only after these aggregates are formed. Aggregation is a two-step process: first, erythrocytes associate in long chains (rouleau formation). Next, these chains form spheres of u...

Intramembrane Particle Aggregation in Erythrocyte Ghosts

We have used freeze-etching and SDS-polyacrylamide gel electrophoresis to study the conditions under which the intramembrane particles of the human erythrocyte ghost may be aggregated. The fibrous membrane protein, spectrin, can be almost entirely removed from erythrocyte ghosts with little or no change in the distribution of the particles. However, after spectrin depletion, particle aggregatio...

Interaction energies in lectin-induced erythrocyte aggregation

Two N-acetylgalactosamine-reactive lectins, Helix pomatia (HPA) and Dolichos biflorus (DBA), were used to study the energies involved in cell-cell interactions through the specific binding of these lectins to their membrane receptors on genotype AO human erythrocytes (red blood cells) (RBCs). The energy required to dissociate a unit of aggregated membrane area (gamma d) of two RBCs bridged by l...

Erythrocyte aggregation in homozygous sickle cell disease.

Amparo Vayáa,∗, Susana Colladoa, Rafael Alisb,c and Maria-Angeles Dası́d aHemorheology and Haemostasis Unit, Service of Clinical Pathology, La Fe University Hospital, Valencia, Spain bResearch Universitary Institute “Dr. Viña Giner”, Molecular and Mitochondrial Medicine, Catholic University of Valencia, “San Vicente Mártir”, Valencia, Spain cFaculty of Medicine, Catholic University of Valencia “...